Switch #:
SWTI000535
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the di-leucine endocytosis motif of PEX5-related protein (Pex5l), abrogating binding to AP-2 complex subunit sigma (Ap2s1). The motif is present in exon 5.

Participants:
(1) PEX5-related protein (Pex5l)
(2) AP-2 complex subunit sigma (Ap2s1)

Interactions
Context
References

(1) TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain.
Santoro et al. Neuron (2009)




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