Description: Alternative splicing removes the nuclear localisation signal (NLS) of Isoform Delta 3 of Calcium/calmodulin-dependent protein kinase type II subunit delta (Camk2d), abrogating binding to Importin subunit alpha-1 (KPNA1) and nuclear import. This is due to an 11 amino acid insert encoded by exon 14.
Participants: (1) Isoform Delta 3 of Calcium/calmodulin-dependent protein kinase type II subunit delta (Camk2d) (2) Importin subunit alpha-1 (KPNA1)
(1) Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus.Srinivasan et al. J. Cell Biol. (1994)
Your browser does not support iframes.