Switch #: SWTI000530

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Binding of the BIR domain-binding motif of Caspase-1 (Dcp-1) to the BIR domains of Apoptosis 1 inhibitor (th) requires cleavage of Caspase-1 (Dcp-1) at D33, since this results in a functional neo N-terminal motif. BIR domains are found in Inhibitor of Apoptosis Proteins (IAPs) that suppress the activity of activated caspases, either by directly inhibiting caspase catalytic activity, or by targeting caspases for degradation by ubiquitin modification.

Participants:
(1) Caspase-1 (Dcp-1)
(2) Apoptosis 1 inhibitor (th)

(1) IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms.
Tenev et al. Nat. Cell Biol. (2005)