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Physicochemical compatibility

Binding of the BIR domain-binding motif of Caspase-9 (CASP9) to the BIR domains of Baculoviral IAP repeat-containing protein 2 (BIRC2) requires cleavage of Caspase-9 (CASP9) at D315, since this results in a functional neo N-terminal motif. BIR domains are found in Inhibitor of Apoptosis Proteins (IAPs) that suppress the activity of activated caspases, either by directly inhibiting caspase catalytic activity, or by targeting caspases for degradation by ubiquitin modification.

(1) Caspase-9 (CASP9)
(2) Baculoviral IAP repeat-containing protein 2 (BIRC2)

Interaction #1 CASP9 - BIRC2

(1) LIG_BIR_III_2 motif (315DATPF319) in Caspase-9 (CASP9)
(2) Inhibitor of Apoptosis domain (272-337) in Baculoviral IAP repeat-containing protein 2 (BIRC2)

Interaction Regulation
PTM-dependent Induction (Proteolytic cleavage at D315 on Caspase-9 (CASP9)) of the Caspase-9 (CASP9) LIG_BIR_III_2 motif - Baculoviral IAP repeat-containing protein 2 (BIRC2) Inhibitor of Apoptosis domain interaction

Additional Information
Affinity : 0.048 µM
Structural information: 3D9T

(1) The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9.
Kulathila et al. Acta Crystallogr. D Biol. Crystallogr. (2009)

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