Switch #: SWTI000528

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Binding of the BIR domain-binding motif of Caspase-9 (CASP9) to the BIR domains of Baculoviral IAP repeat-containing protein 2 (BIRC2) requires cleavage of Caspase-9 (CASP9) at D315, since this results in a functional neo N-terminal motif. BIR domains are found in Inhibitor of Apoptosis Proteins (IAPs) that suppress the activity of activated caspases, either by directly inhibiting caspase catalytic activity, or by targeting caspases for degradation by ubiquitin modification.

Participants:
(1) Caspase-9 (CASP9)
(2) Baculoviral IAP repeat-containing protein 2 (BIRC2)

(1) The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9.
Kulathila et al. Acta Crystallogr. D Biol. Crystallogr. (2009)