Switches.ELM

Switch #:

SWTI000523

Switch type:
Binary

Description:
Alternative promoter usage removes the mitochondrial localisation signal (MLS) of Isoform UNG1 of Uracil-DNA glycosylase (UNG), abrogating binding to Mitochondrial import receptor subunit TOM70 (TOMM70A) and import into mitochondria. In Isoform UNG2 of Uracil-DNA glycosylase (UNG) the MLS present in Isoform UNG1 of Uracil-DNA glycosylase (UNG) is replaced with a nuclear localisation signal (NLS), promoting different localisations of the different protein isoforms.

Participants:
(1) Isoform UNG1 of Uracil-DNA glycosylase (UNG)
(2) Mitochondrial import receptor subunit TOM70 (TOMM70A)

Interactions

Interaction #1 UNG - TOMM70A

Interfaces
(1) ELM:TRG_MLS motif (₁MGVFCLGPWGLGRKLRTPGKGPLQLLSRLCGDHLQAIPAKKAPA₄₄) in Isoform UNG1 of Uracil-DNA glycosylase (UNG)
(2) Tetratricopeptide repeat_(114-578) in Mitochondrial import receptor subunit TOM70 (TOMM70A)

Interaction Regulation
Alternative promoter usage Abrogation of the Isoform UNG1 of Uracil-DNA glycosylase (UNG) TRG_MLS motif - Mitochondrial import receptor subunit TOM70 (TOMM70A) Tetratricopeptide repeat interaction

References

(1) Identification of sequence determinants of human nuclear dUTPase isoform localization.
Tinkelenberg et al. Exp. Cell Res. (2003)