Switch #: SWTI000521

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the PCNA-binding motif of Isoform Variant A of Inhibitor of growth protein 1 (ING1), abrogating binding to Proliferating cell nuclear antigen (PCNA). P33-ING1b (also known as Isoform Variant A of Inhibitor of growth protein 1 (ING1)) binds specially to PCNA, resulting in a major change in subcellular localisation and the import of this isoform into the nucleus. This is theorised to act by limiting access to the PCNA-binding domain but eventually it promotes apoptosis (though this may not be its physiological effect).

Participants:
(1) Isoform Variant A of Inhibitor of growth protein 1 (ING1)
(2) Proliferating cell nuclear antigen (PCNA)

(1) UV-induced binding of ING1 to PCNA regulates the induction of apoptosis.
Scott et al. J. Cell. Sci. (2001)