Switch #:
SWTI000518
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the nuclear export signal (NES) of Cellular tumor antigen p53 (TP53), abrogating binding to Exportin-1 (XPO1) and export from the nucleus.

Participants:
(1) Cellular tumor antigen p53 (TP53)
(2) Exportin-1 (XPO1)

Interactions
Interaction #1 TP53 - XPO1

Interfaces
(1) TRG_NES_CRM1_1 motif (339EMFRELNEALELKD352) in Cellular tumor antigen p53 (TP53)
(2) Exportin 1-like protein (123-268) in Exportin-1 (XPO1)

Interaction Regulation
Alternative splicing Abrogation of the Cellular tumor antigen p53 (TP53) TRG_NES_CRM1_1 motif - Exportin-1 (XPO1) Exportin 1-like protein interaction

Context
Switch localisation
Curated: nucleus
ELM curated: nucleus, cytosol
Inferred: nucleolus, cytosol
References

(1) p53 isoforms can regulate p53 transcriptional activity.
Bourdon et al. Genes Dev. (2005)

(2) p53 isoforms - a conspiracy to kidnap p53 tumor suppressor activity?
Marcel et al. Cell. Mol. Life Sci. (2009)




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