Description: Participants: Interactions Interaction #1 TP53 - MDM2 Interfaces (1) DEG_MDM2_1 motif (19FSDLWKLL26) in Cellular tumor antigen p53 (TP53) (2) SWIB/MDM2 domain (27-102) in E3 ubiquitin-protein ligase Mdm2 (MDM2) Interaction Regulation Alternative promoter usage and alternative splicing Abrogation of the Cellular tumor antigen p53 (TP53) DEG_MDM2_1 motif - E3 ubiquitin-protein ligase Mdm2 (MDM2) SWIB/MDM2 domain interaction Context Switch localisation ELM curated: nucleus, cytosol Switch cell cycle phase Curated: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Switch pathways References (1) DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53. |
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