Switch #:
SWTI000510
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the 14-3-3-binding motif of Slowpoke-binding protein (Slob), abrogating binding to 14-3-3 family. Another 14-3-3 motif exists in this protein (50-RSNS-54) that is not altered by Alternative splicing. The removal of this motif therefore decreases the avidity of the interaction with 14-3-3 proteins.

Participants:
(1) Slowpoke-binding protein (Slob)
(2) 14-3-3 family

Interactions
Interaction #1 Slob - 14-3-3 family

Interfaces
(1) LIG_14-3-3_3 motif (76RSASSE81) in Slowpoke-binding protein (Slob)
(2) 14-3-3 protein (-) in 14-3-3 family

Interaction Regulation
Alternative splicing Abrogation of the Slowpoke-binding protein (Slob) LIG_14-3-3_3 motif - 14-3-3 family 14-3-3 protein interaction

Context
References

(1) Expression and function of variants of slob, slowpoke channel binding protein, in Drosophila.
Jaramillo et al. J. Neurophysiol. (2006)




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