Switch #:
SWTI000499
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the PDZ-binding motif of Isoform 5-HT4(E) of 5-hydroxytryptamine receptor 4 (Htr4), abrogating binding to InaD-like protein (Inadl).

Participants:
(1) Isoform 5-HT4(E) of 5-hydroxytryptamine receptor 4 (Htr4)
(2) InaD-like protein (Inadl)

Interactions
Interaction #1 Htr4 - Inadl

Interfaces
(1) LIG_PDZ_Class_2 motif (368PVPV371) in Isoform 5-HT4(E) of 5-hydroxytryptamine receptor 4 (Htr4)
(2) PDZ domain (Also known as DHR or GLGF) (134-221) and (248-328) and (365-453) and (555-641) in InaD-like protein (Inadl)

Interaction Regulation
Alternative splicing Abrogation of the Isoform 5-HT4(E) of 5-hydroxytryptamine receptor 4 (Htr4) LIG_PDZ_Class_2 motif - InaD-like protein (Inadl) PDZ domain (Also known as DHR or GLGF) interaction

Context
References

(1) New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting.
Joubert et al. J. Cell. Sci. (2004)




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