Switch #:
SWTI000494
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the Dynein-binding motif of Bcl-2-like protein 11 (BCL2L11), abrogating binding to Dynein light chain 1, cytoplasmic (DYNLL1). Most BCL2L11 in healthy cells is sequestered away bound to DYNLL1 (the exception is Bim-S Isoform BCL2-like 11 transcript variant 9 of Bcl-2-like protein 11 (BCL2L11)). Cells exposed to environmental stress up-regulate c-Jun NH(2)-terminal kinases (JNK) that phosphorylate both BCL2L11 and BMF, releasing them from motor complexes and promoting apoptosis.

Participants:
(1) Bcl-2-like protein 11 (BCL2L11)
(2) Dynein light chain 1, cytoplasmic (DYNLL1)

Interactions
Context
References

(1) The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex.
Puthalakath et al. Mol. Cell (1999)




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