Switch #:
SWTI000489
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the SH3-binding motif of Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15), abrogating binding to Proto-oncogene tyrosine-protein kinase Src (SRC). The overexpression of this splice variant has been linked to clinical aggressiveness of breast cancer.

Participants:
(1) Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15)
(2) Proto-oncogene tyrosine-protein kinase Src (SRC)

Interactions
Context
References

(1) Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer.
Maretzky et al. Cancer Res. (2009)




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