Switch #:
SWTI000487
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the PDZ-binding motif of Plasma membrane calcium-transporting ATPase 4 (ATP2B4), abrogating binding to Peripheral plasma membrane protein CASK (CASK). The PDZ domain-containing protein CASK and PMCA4b co-precipitate in kidney and brain. Similar to NOS1, binding to PMCA4b allows Ca2+ dependent regulation. Depletion of local Ca2+ by PMCA4b in close proximity to CASK may inhibit Ca2+/calmodulin binding. This can subsequently inhibit binding to T-box brain protein 1 (TBR1) and/or translocation of CASK or the CASK/TBR1 complex to the nucleus.

Participants:
(1) Plasma membrane calcium-transporting ATPase 4 (ATP2B4)
(2) Peripheral plasma membrane protein CASK (CASK)

Interactions
Interaction #1 ATP2B4 - CASK

Interfaces
(1) LIG_PDZ_Class_1 motif (1236SLETSV1241) in Plasma membrane calcium-transporting ATPase 4 (ATP2B4)
(2) PDZ domain (Also known as DHR or GLGF) (489-564) in Peripheral plasma membrane protein CASK (CASK)

Interaction Regulation
Alternative splicing Abrogation of the Plasma membrane calcium-transporting ATPase 4 (ATP2B4) LIG_PDZ_Class_1 motif - Peripheral plasma membrane protein CASK (CASK) PDZ domain (Also known as DHR or GLGF) interaction

Context
Switch localisation
ELM curated: cytosol, internal side of plasma membrane
References

(1) Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK.
Schuh et al. J. Biol. Chem. (2003)




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