Switch #:
SWTI000475
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing strongly inhibits the binding of the filamin-binding motif of Integrin beta-1 (ITGB1) to Filamin-A (FLNA), primarily due to the alteration of A to P it seems.

Participants:
(1) Integrin beta-1 (ITGB1)
(2) Filamin-A (FLNA)

Interactions
Interaction #1 ITGB1 - FLNA

Interfaces
(1) ELM:LIG_Filamin_2 motif (783YKSAVTTVV791) in Integrin beta-1 (ITGB1)
(2) Filamin/ABP280 repeat (2235-2322) in Filamin-A (FLNA)

Interaction Regulation
Alternative splicing Inhibition of the Integrin beta-1 (ITGB1) LIG_Filamin_2 motif - Filamin-A (FLNA) Filamin/ABP280 repeat interaction

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane


Switch pathways
Inferred: Focal adhesion
References

(1) Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.
van der Flier et al. J. Cell Biol. (2002)

(2) The molecular basis of filamin binding to integrins and competition with talin.
Kiema et al. Mol. Cell (2006)




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