Switch #:
SWTI000463
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the WW-binding motif of Angiomotin (AMOT), abrogating binding to Yorkie homolog (YAP1). The splice specific Isoform p130 of Angiomotin (AMOT) of AMOT works within the Hippo pathway to sequester the transcription coactivator YAP1 away at tight junction. In contrast Isoform p80 of Angiomotin (AMOT) of AMOT lacks WW-binding motif.

Participants:
(1) Angiomotin (AMOT)
(2) Yorkie homolog (YAP1)

Interactions
Interaction #1 AMOT - YAP1

Interfaces
(1) LIG_WW_1 motif (239PPEY242) in Angiomotin (AMOT)
(2) WW domain (171-204) in Yorkie homolog (YAP1)

Interaction Regulation
Alternative splicing Abrogation of the Angiomotin (AMOT) LIG_WW_1 motif - Yorkie homolog (YAP1) WW domain interaction

Context
Switch localisation
ELM curated: cytosol, integral membrane protein, integral plasma membrane protein
Inferred: cytosol
References

(1) Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein.
Zhao et al. Genes Dev. (2011)

(2) Differential roles of p80- and p130-angiomotin in the switch between migration and stabilization of endothelial cells.
Ernkvist et al. Biochim. Biophys. Acta (2008)




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