Switch #:
SWTI000462
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T56 by Mitogen-activated protein kinase 8 (MAPK8) in the Dynein-binding motif of Isoform Bim(L) of Bcl-2-like protein 11 (BCL2L11) inhibits binding to Dynein light chain 1, cytoplasmic (DYNLL1). Most Bim in healthy cells is sequestered away bound to light chain dynein molecules. Cells exposed to environmental stress up-regulate c-Jun NH(2)-terminal kinase (JNK) that phosphorylates both Bim and Bmf, releasing them from motor complexes and promoting apoptosis.

Participants:
(1) Isoform Bim(L) of Bcl-2-like protein 11 (BCL2L11)
(2) Dynein light chain 1, cytoplasmic (DYNLL1)

Interactions
Interaction #1 BCL2L11 - DYNLL1

Interfaces
(1) LIG_Dynein_DLC8_1 motif (50CDKSTQT56) in Isoform Bim(L) of Bcl-2-like protein 11 (BCL2L11)
(2) Dynein light chain type 1 (1-89) in Dynein light chain 1, cytoplasmic (DYNLL1)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of T56 on Isoform Bim(L) of Bcl-2-like protein 11 (BCL2L11)) of the Isoform Bim(L) of Bcl-2-like protein 11 (BCL2L11) LIG_Dynein_DLC8_1 motif - Dynein light chain 1, cytoplasmic (DYNLL1) Dynein light chain type 1 interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: T56: Mitogen-activated protein kinase 8 (MAPK8)

Context
Switch localisation
ELM curated: dynein complex, cytosol, cytoplasmic dynein complex
Inferred: cytosol, plasma membrane
References

(1) JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis.
Lei et al. Proc. Natl. Acad. Sci. U.S.A. (2003)




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