Description: Phosphorylation of T238 in MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) by Cyclin-dependent kinase 1 (CDK1) primes for phosphorylation of T234 by Glycogen synthase kinase-3 beta (GSK3B), which primes for phosphorylation of S230 by Glycogen synthase kinase-3 beta (GSK3B). Triple-phosphorylated hNIFK (MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)) binds strongly to Antigen KI-67 (MKI67). See also switch details
Participants: (1) MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP) (2) Antigen KI-67 (MKI67)
(1) Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67.Byeon et al. Nat. Struct. Mol. Biol. (2005)
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