Description: Participants: Interactions Interaction #1 DAXX - SUMO1 Interfaces (1) LIG_SUMO_SBM_1 motif (734IVLSDSD740) in Death domain-associated protein 6 (DAXX) (2) Ubiquitin-2 like Rad60 SUMO-like (22-92) in Small ubiquitin-related modifier 1 (SUMO1) Interaction Regulation PTM-dependent Enhancement (Phosphorylation of S737 and S739 on Death domain-associated protein 6 (DAXX)) of the Death domain-associated protein 6 (DAXX) LIG_SUMO_SBM_1 motif - Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin-2 like Rad60 SUMO-like interaction Regulatory Enzymes for switch Modifying enzymes for residue: S737: CK2 subfamily; S739: CK2 subfamily Inferred Regulatory Enzymes for switch Putative modifying enzymes for residue: S737 : Casein kinase II subunit alpha (CSNK2A1). S739 : Casein kinase II subunit alpha (CSNK2A1). Additional Information Affinity : Daxx(721-740): 55.3 (+/-14.2) µM, Daxx(721-740)-pS737: 4.6 (+/-1.2) µM, Daxx(721-740)-pS739: 2.8 (+/-0.3) µM, Daxx(721-740)-pS737-pS739: 1.6 (+/-0.4) µM Structural information: 2KQS References (1) Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation. |
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