Switch #:
SWTI000450
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1138 in the SH2-binding motif of Leptin receptor (Lepr) induces binding to the Signal transducer and activator of transcription 3 (STAT3) protein.

Participants:
(1) Leptin receptor (Lepr)
(2) Signal transducer and activator of transcription 3 (STAT3)

Interactions
Interaction #1 Lepr - STAT3

Interfaces
(1) ELM:LIG_SH2_III motif (1129GTSGENFVPYMPQFQTCSTH1148) in Leptin receptor (Lepr)
(2) SH2 domain (584-674) in Signal transducer and activator of transcription 3 (STAT3)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1138 on Leptin receptor (Lepr)) of the Leptin receptor (Lepr) LIG_SH2_III motif - Signal transducer and activator of transcription 3 (STAT3) SH2 domain interaction

References

(1) Activation of downstream signals by the long form of the leptin receptor.
Banks et al. J. Biol. Chem. (2000)




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