Switch #:
SWTI000447
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y323 in the SH2-binding motif of Tyrosine-protein kinase SYK (SYK) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.

Participants:
(1) Tyrosine-protein kinase SYK (SYK)
(2) E3 ubiquitin-protein ligase CBL-B (CBLB)

Interactions
Interaction #1 SYK - CBLB

Interfaces
(1) ELM:LIG_SH2_IIC motif (315ESTVSFNPYEPELAPWA331) in Tyrosine-protein kinase SYK (SYK)
(2) E3 ubiquitin-protein ligase CBL-B (CBLB)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y323 on Tyrosine-protein kinase SYK (SYK)) of the Tyrosine-protein kinase SYK (SYK) LIG_SH2_IIC motif - E3 ubiquitin-protein ligase CBL-B (CBLB) interaction

Context
Switch localisation
Inferred: cytosol
References

(1) Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation.
Elly et al. Oncogene (1999)




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