Switch #:
SWTI000446
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y292 in the SH2-binding motif of Tyrosine-protein kinase ZAP-70 (ZAP70) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.

Participants:
(1) Tyrosine-protein kinase ZAP-70 (ZAP70)
(2) E3 ubiquitin-protein ligase CBL-B (CBLB)

Interactions
Interaction #1 ZAP70 - CBLB

Interfaces
(1) ELM:LIG_SH2_IIC motif (284IDTLNSDGYTPEPARIT300) in Tyrosine-protein kinase ZAP-70 (ZAP70)
(2) E3 ubiquitin-protein ligase CBL-B (CBLB)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y292 on Tyrosine-protein kinase ZAP-70 (ZAP70)) of the Tyrosine-protein kinase ZAP-70 (ZAP70) LIG_SH2_IIC motif - E3 ubiquitin-protein ligase CBL-B (CBLB) interaction


Context
Switch localisation


Switch pathways
References

(1) A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells.
Zhang et al. Curr. Biol. (1999)




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