Description: Phosphorylation of Y292 in the SH2-binding motif of Tyrosine-protein kinase ZAP-70 (ZAP70) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.
Participants: (1) Tyrosine-protein kinase ZAP-70 (ZAP70) (2) E3 ubiquitin-protein ligase CBL-B (CBLB)
(1) A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells.Zhang et al. Curr. Biol. (1999)
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