Switch #:
SWTI000445
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y694 in the SH2-binding motif of Signal transducer and activator of transcription 5A (STAT5A) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.

Participants:
(1) Signal transducer and activator of transcription 5A (STAT5A)
(2) Signal transducer and activator of transcription 5B (STAT5B)

Interactions
Interaction #1 STAT5A - STAT5B

Interfaces
(1) ELM:LIG_SH2_III motif (686VLAKAVDGYVKPQIKQV702) in Signal transducer and activator of transcription 5A (STAT5A)
(2) SH2 domain (593-670) in Signal transducer and activator of transcription 5B (STAT5B)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y694 on Signal transducer and activator of transcription 5A (STAT5A)) of the Signal transducer and activator of transcription 5A (STAT5A) LIG_SH2_III motif - Signal transducer and activator of transcription 5B (STAT5B) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y694 : Tyrosine-protein kinase Lyn (LYN), Tyrosine-protein kinase JAK3 (JAK3), Tyrosine-protein kinase Lck (LCK), Tyrosine-protein kinase Lyn (Lyn), Tyrosine-protein kinase SYK (SYK), Tyrosine-protein kinase JAK2 (JAK2), Proto-oncogene tyrosine-protein kinase Src (SRC).

Context
Switch localisation
Curated: cytosol
Inferred: nucleoplasm, cytosol
References

(1) A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation.
Barber et al. Blood (2001)




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