Switch #:
SWTI000443
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y220 in the SH2-binding motif of Disabled homolog 1 (Dab1) induces binding to the Cytoplasmic protein NCK2 (NCK2) protein.

Participants:
(1) Disabled homolog 1 (Dab1)
(2) Cytoplasmic protein NCK2 (NCK2)

Interactions
Interaction #1 Dab1 - NCK2

Interfaces
(1) ELM:LIG_SH2_IA motif (212DPETEENIYQVPTSQKK228) in Disabled homolog 1 (Dab1)
(2) SH2 domain (285-323) in Cytoplasmic protein NCK2 (NCK2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y220 on Disabled homolog 1 (Dab1)) of the Disabled homolog 1 (Dab1) LIG_SH2_IA motif - Cytoplasmic protein NCK2 (NCK2) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y220 : Tyrosine-protein kinase ABL1 (ABL1), Neuronal proto-oncogene tyrosine-protein kinase Src (Src), Proto-oncogene tyrosine-protein kinase Src (SRC).

References

(1) Nck beta interacts with tyrosine-phosphorylated disabled 1 and redistributes in Reelin-stimulated neurons.
Pramatarova et al. Mol. Cell. Biol. (2003)




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