Switch #:
SWTI000442
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y20 in the SH2-binding motif of Dermcidin (DCD) induces binding to the Cytoplasmic protein NCK1 (NCK1) protein.

Participants:
(1) Dermcidin (DCD)
(2) Cytoplasmic protein NCK1 (NCK1)

Interactions
Interaction #1 DCD - NCK1

Interfaces
(1) ELM:LIG_SH2_IA motif (15ALVCAYDPEAA25) in Dermcidin (DCD)
(2) SH2 domain (282-356) in Cytoplasmic protein NCK1 (NCK1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y20 on Dermcidin (DCD)) of the Dermcidin (DCD) LIG_SH2_IA motif - Cytoplasmic protein NCK1 (NCK1) SH2 domain interaction

References

(1) Identification of Dermcidin as a novel binding protein of Nck1 and characterization of its role in promoting cell migration.
Shen et al. Biochim. Biophys. Acta (2011)




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