Switch #:
SWTI000437
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y727 in the SH2-binding motif of BDNF/NT-3 growth factors receptor (NTRK2) induces binding to the Cytoplasmic protein NCK2 (NCK2) protein.

Participants:
(1) BDNF/NT-3 growth factors receptor (NTRK2)
(2) Cytoplasmic protein NCK2 (NCK2)

Interactions
Interaction #1 NTRK2 - NCK2

Interfaces
(1) ELM:LIG_SH2_IA motif (714MLPIRWMPPESIMYRKF730) in BDNF/NT-3 growth factors receptor (NTRK2)
(2) SH2 domain (285-323) in Cytoplasmic protein NCK2 (NCK2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y727 on BDNF/NT-3 growth factors receptor (NTRK2)) of the BDNF/NT-3 growth factors receptor (NTRK2) LIG_SH2_IA motif - Cytoplasmic protein NCK2 (NCK2) SH2 domain interaction

Context
Switch localisation
Inferred: cytosol
References

(1) Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor.
Suzuki et al. Biochem. Biophys. Res. Commun. (2002)




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