Switches.ELM

Switch #:

SWTI000435

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y281 in the SH2-binding motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding to the SH2 domain-containing protein 1B (Sh2d1b) protein.

Participants:
(1) Signaling lymphocytic activation molecule (SLAMF1)
(2) SH2 domain-containing protein 1B (Sh2d1b)

Interactions

Interaction #1 SLAMF1 - Sh2d1b

Interfaces
(1) ELM:LIG_SH2_IB motif (₂₇₃VEKKSLTIYAQVQK₂₈₆) in Signaling lymphocytic activation molecule (SLAMF1)
(2) SH2 domain_(5-86) in SH2 domain-containing protein 1B (Sh2d1b)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y₂₈₁ on Signaling lymphocytic activation molecule (SLAMF1)) of the Signaling lymphocytic activation molecule (SLAMF1) LIG_SH2_IB motif - SH2 domain-containing protein 1B (Sh2d1b) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y₂₈₁ : Tyrosine-protein kinase Fyn (FYN).

Additional Information
Structural information: 1I3Z

References

(1) Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
Morra et al. EMBO J. (2001)