Switches.ELM

Switch #:

SWTI000434

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y281 in the SH2-binding motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding to the SH2 domain-containing protein 1A (SH2D1A) protein.

Participants:
(1) Signaling lymphocytic activation molecule (SLAMF1)
(2) SH2 domain-containing protein 1A (SH2D1A)

Interactions

Interaction #1 SLAMF1 - SH2D1A

Interfaces
(1) ELM:LIG_SH2_IB motif (₂₇₆KSLTIYAQVQK₂₈₆) in Signaling lymphocytic activation molecule (SLAMF1)
(2) SH2 domain_(4-87) in SH2 domain-containing protein 1A (SH2D1A)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y₂₈₁ on Signaling lymphocytic activation molecule (SLAMF1)) of the Signaling lymphocytic activation molecule (SLAMF1) LIG_SH2_IB motif - SH2 domain-containing protein 1A (SH2D1A) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y₂₈₁ : Tyrosine-protein kinase Fyn (FYN).

Additional Information
Structural information: 1D4T

References

(1) Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Poy et al. Mol. Cell (1999)