Switch #:
SWTI000432
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y128 in the SH2-binding motif of Lymphocyte cytosolic protein 2 (LCP2) induces binding to the SH2 domain-containing adapter protein B (SHB) protein.

Participants:
(1) Lymphocyte cytosolic protein 2 (LCP2)
(2) SH2 domain-containing adapter protein B (SHB)

Interactions
Interaction #1 LCP2 - SHB

Interfaces
(1) ELM:LIG_SH2_IIB motif (120QDGEDDGDYESPNE133) in Lymphocyte cytosolic protein 2 (LCP2)
(2) SH2 domain (410-485) in SH2 domain-containing adapter protein B (SHB)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y128 on Lymphocyte cytosolic protein 2 (LCP2)) of the Lymphocyte cytosolic protein 2 (LCP2) LIG_SH2_IIB motif - SH2 domain-containing adapter protein B (SHB) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y128 : Tyrosine-protein kinase Lck (LCK), Tyrosine-protein kinase SYK (SYK), Tyrosine-protein kinase ZAP-70 (ZAP70).

References

(1) Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.
Lindholm et al. Eur. J. Biochem. (2002)




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