Switch #:
SWTI000430
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y397 in the SH2-binding motif of Focal adhesion kinase 1 (PTK2) induces binding to the Cytoplasmic protein NCK2 (NCK2) protein.

Participants:
(1) Focal adhesion kinase 1 (PTK2)
(2) Cytoplasmic protein NCK2 (NCK2)

Interactions
Interaction #1 PTK2 - NCK2

Interfaces
(1) ELM:LIG_SH2_IA motif (389VSVSETDDYAEIIDEED405) in Focal adhesion kinase 1 (PTK2)
(2) SH2 domain (285-323) in Cytoplasmic protein NCK2 (NCK2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y397 on Focal adhesion kinase 1 (PTK2)) of the Focal adhesion kinase 1 (PTK2) LIG_SH2_IA motif - Cytoplasmic protein NCK2 (NCK2) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y397 : Tyrosine-protein kinase Fgr (FGR), Hepatocyte growth factor receptor (MET), Proto-oncogene tyrosine-protein kinase Src (SRC), Focal adhesion kinase 1 (PTK2).

Context
Switch localisation
Inferred: cytosol


Switch pathways
Inferred: Axon guidance, ErbB signaling pathway
References

(1) Nck-2 interacts with focal adhesion kinase and modulates cell motility.
Goicoechea et al. Int. J. Biochem. Cell Biol. (2002)




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