Switch #:
SWTI000423
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y392 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.

Participants:
(1) Fibroblast growth factor receptor substrate 2 (FRS2)
(2) Growth factor receptor-bound protein 2 (GRB2)

Interactions
Interaction #1 FRS2 - GRB2

Interfaces
(1) ELM:LIG_SH2_IC motif (385NLDPMHNYVNT395) in Fibroblast growth factor receptor substrate 2 (FRS2)
(2) SH2 domain (60-135) in Growth factor receptor-bound protein 2 (GRB2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y392 on Fibroblast growth factor receptor substrate 2 (FRS2)) of the Fibroblast growth factor receptor substrate 2 (FRS2) LIG_SH2_IC motif - Growth factor receptor-bound protein 2 (GRB2) SH2 domain interaction

Context
Switch localisation


Switch pathways
References

(1) Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor.
Zhang et al. Mol. Endocrinol. (2008)




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