Switch #:
SWTI000415
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y713 in the SH2-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the SHC-transforming protein 1 (SHC1) protein.

Participants:
(1) Interleukin-4 receptor subunit alpha (IL4R)
(2) SHC-transforming protein 1 (SHC1)

Interactions
Interaction #1 IL4R - SHC1

Interfaces
(1) ELM:LIG_SH2_IIB motif (706SLGSGIVYSALTCHLC721) in Interleukin-4 receptor subunit alpha (IL4R)
(2) SH2 domain (488-559) in SHC-transforming protein 1 (SHC1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y713 on Interleukin-4 receptor subunit alpha (IL4R)) of the Interleukin-4 receptor subunit alpha (IL4R) LIG_SH2_IIB motif - SHC-transforming protein 1 (SHC1) SH2 domain interaction

Context
References

(1) Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation.
Kashiwada et al. J. Immunol. (2001)




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