Switch #:
SWTI000414
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y713 in the SH2-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) protein.

Participants:
(1) Interleukin-4 receptor subunit alpha (IL4R)
(2) Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

Interactions
Interaction #1 IL4R - PTPN11

Interfaces
(1) ELM:LIG_SH2_IIA motif (706SLGSGIVYSALTCHLC721) in Interleukin-4 receptor subunit alpha (IL4R)
(2) SH2 domain (112-197) in Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y713 on Interleukin-4 receptor subunit alpha (IL4R)) of the Interleukin-4 receptor subunit alpha (IL4R) LIG_SH2_IIA motif - Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) SH2 domain interaction

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane


Switch pathways
Inferred: Jak-STAT signaling pathway
References

(1) Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation.
Kashiwada et al. J. Immunol. (2001)




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