Switch #:
SWTI000393
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y536 in the SH2-binding motif of Interleukin-2 receptor subunit beta (IL2RB) induces binding to the Signal transducer and activator of transcription 5A (STAT5A) protein.

Participants:
(1) Interleukin-2 receptor subunit beta (IL2RB)
(2) Signal transducer and activator of transcription 5A (STAT5A)

Interactions
Interaction #1 IL2RB - STAT5A

Interfaces
(1) ELM:LIG_SH2_III motif (531LNTDAYLSLQ540) in Interleukin-2 receptor subunit beta (IL2RB)
(2) SH2 domain (593-670) in Signal transducer and activator of transcription 5A (STAT5A)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y536 on Interleukin-2 receptor subunit beta (IL2RB)) of the Interleukin-2 receptor subunit beta (IL2RB) LIG_SH2_III motif - Signal transducer and activator of transcription 5A (STAT5A) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y536 : Tyrosine-protein kinase Lck (LCK).

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane


Switch pathways
Inferred: Jak-STAT signaling pathway
References

(1) Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain.
Delespine-Carmagnat et al. Eur. J. Immunol. (2000)




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