Switch #:
SWTI000388
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y751 in the SH2-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) induces binding to the Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) protein.

Participants:
(1) Platelet-derived growth factor receptor beta (PDGFRB)
(2) Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Interactions
Interaction #1 PDGFRB - PIK3R1

Interfaces
(1) ELM:LIG_SH2_IIA motif (751YVPML755) in Platelet-derived growth factor receptor beta (PDGFRB)
(2) SH2 domain (624-698) in Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y751 on Platelet-derived growth factor receptor beta (PDGFRB)) of the Platelet-derived growth factor receptor beta (PDGFRB) LIG_SH2_IIA motif - Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y751 : PDGFR_group, Platelet-derived growth factor receptor beta (PDGFRB).

Additional Information
Structural information: 1H9O
Context
References

(1) NMR trial models: experiences with the colicin immunity protein Im7 and the p85alpha C-terminal SH2-peptide complex.
Pauptit et al. Acta Crystallogr. D Biol. Crystallogr. (2001)




Loading visualisation