Switch #:
SWTI000385
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y791 in the SH2-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the Megakaryocyte-associated tyrosine-protein kinase (MATK) protein.

Participants:
(1) High affinity nerve growth factor receptor (NTRK1)
(2) Megakaryocyte-associated tyrosine-protein kinase (MATK)

Interactions
Interaction #1 NTRK1 - MATK

Interfaces
(1) ELM:LIG_SH2_IB motif (783ALAQAPPVYLDVLG796) in High affinity nerve growth factor receptor (NTRK1)
(2) SH2 domain (122-196) in Megakaryocyte-associated tyrosine-protein kinase (MATK)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y791 on High affinity nerve growth factor receptor (NTRK1)) of the High affinity nerve growth factor receptor (NTRK1) LIG_SH2_IB motif - Megakaryocyte-associated tyrosine-protein kinase (MATK) SH2 domain interaction


Context
References

(1) The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells.
Yamashita et al. J. Biol. Chem. (1999)




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