Switch #:
SWTI000384
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y791 in the SH2-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein.

Participants:
(1) High affinity nerve growth factor receptor (NTRK1)
(2) SHC-transforming protein 1 (SHC1)

Interactions
Interaction #1 NTRK1 - SHC1

Interfaces
(1) ELM:LIG_SH2_IIB motif (782QALAQAPPVYLDVLG796) in High affinity nerve growth factor receptor (NTRK1)
(2) SH2 domain (488-559) in SHC-transforming protein 1 (SHC1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y791 on High affinity nerve growth factor receptor (NTRK1)) of the High affinity nerve growth factor receptor (NTRK1) LIG_SH2_IIB motif - SHC-transforming protein 1 (SHC1) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y791 : High affinity nerve growth factor receptor (NTRK1).

Context

Switch pathways
Inferred: Neurotrophin signaling pathway
References

(1) Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor.
Mardy et al. Hum. Mol. Genet. (2001)




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