Switches.ELM

Switch #:

SWTI000382

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1023 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-2 (ERBB2) induces binding to the SH2 domain-containing protein 3A (SH2D3A) protein.

Participants:
(1) Receptor tyrosine-protein kinase erbB-2 (ERBB2)
(2) SH2 domain-containing protein 3A (SH2D3A)

Interactions

Interaction #1 ERBB2 - SH2D3A

Interfaces
(1) ELM:LIG_SH2_ID motif (₁₀₁₅GDLVDAEEYLVPQQGFF₁₀₃₁) in Receptor tyrosine-protein kinase erbB-2 (ERBB2)
(2) SH2 domain_(15-95) in SH2 domain-containing protein 3A (SH2D3A)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y₁₀₂₃ on Receptor tyrosine-protein kinase erbB-2 (ERBB2)) of the Receptor tyrosine-protein kinase erbB-2 (ERBB2) LIG_SH2_ID motif - SH2 domain-containing protein 3A (SH2D3A) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y₁₀₂₃ : Receptor tyrosine-protein kinase erbB-2 (ERBB2).

Context

References

(1) A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Jones et al. Nature (2006)