Switch #:
SWTI000381
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1139 in the SH2-binding motif of Receptor tyrosine-protein kinase erbB-2 (ERBB2) induces binding to the Breast cancer anti-estrogen resistance protein 3 (BCAR3) protein.

Participants:
(1) Receptor tyrosine-protein kinase erbB-2 (ERBB2)
(2) Breast cancer anti-estrogen resistance protein 3 (BCAR3)

Interactions
Interaction #1 ERBB2 - BCAR3

Interfaces
(1) ELM:LIG_SH2_ID motif (1131LTCSPQPEYVNQPDVRP1147) in Receptor tyrosine-protein kinase erbB-2 (ERBB2)
(2) SH2 domain (154-234) in Breast cancer anti-estrogen resistance protein 3 (BCAR3)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1139 on Receptor tyrosine-protein kinase erbB-2 (ERBB2)) of the Receptor tyrosine-protein kinase erbB-2 (ERBB2) LIG_SH2_ID motif - Breast cancer anti-estrogen resistance protein 3 (BCAR3) SH2 domain interaction


Context
References

(1) A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Jones et al. Nature (2006)




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