Switch #:
SWTI000373
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Tyrosine-protein kinase JAK1 (JAK1) protein.

Participants:
(1) Epidermal growth factor receptor (EGFR)
(2) Tyrosine-protein kinase JAK1 (JAK1)

Interactions
Interaction #1 EGFR - JAK1

Interfaces
(1) ELM:LIG_SH2_IE motif (1008DDVVDADEYLIPQQGFF1024) in Epidermal growth factor receptor (EGFR)
(2) Tyrosine-protein kinase JAK1 (JAK1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1016 on Epidermal growth factor receptor (EGFR)) of the Epidermal growth factor receptor (EGFR) LIG_SH2_IE motif - Tyrosine-protein kinase JAK1 (JAK1) interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y1016 : Tyrosine-protein kinase ABL1 (ABL1), Epidermal growth factor receptor (EGFR), Proto-oncogene tyrosine-protein kinase Src (SRC).

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane
Inferred: nucleus


Switch pathways
Inferred: PI3K-Akt signaling pathway
References

(1) A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Jones et al. Nature (2006)




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