Switch #:
SWTI000371
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Ras and Rab interactor 1 (RIN1) protein.

Participants:
(1) Epidermal growth factor receptor (EGFR)
(2) Ras and Rab interactor 1 (RIN1)

Interactions
Interaction #1 EGFR - RIN1

Interfaces
(1) ELM:LIG_SH2_IE motif (1011VDADEYLIPQ1020) in Epidermal growth factor receptor (EGFR)
(2) Ras and Rab interactor 1 (RIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1016 on Epidermal growth factor receptor (EGFR)) of the Epidermal growth factor receptor (EGFR) LIG_SH2_IE motif - Ras and Rab interactor 1 (RIN1) interaction


Context
References

(1) The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis.
Barbieri et al. J. Biol. Chem. (2003)




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