Switch #:
SWTI000370
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.

Participants:
(1) Epidermal growth factor receptor (EGFR)
(2) Growth factor receptor-bound protein 2 (GRB2)

Interactions
Interaction #1 EGFR - GRB2

Interfaces
(1) ELM:LIG_SH2_IC motif (1092YINQSVPKR1100) in Epidermal growth factor receptor (EGFR)
(2) SH2 domain (60-135) in Growth factor receptor-bound protein 2 (GRB2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1092 on Epidermal growth factor receptor (EGFR)) of the Epidermal growth factor receptor (EGFR) LIG_SH2_IC motif - Growth factor receptor-bound protein 2 (GRB2) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y1092 : Tyrosine-protein kinase ABL1 (ABL1), Neuronal proto-oncogene tyrosine-protein kinase Src (Src), Epidermal growth factor receptor (EGFR).

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane
Inferred: endosome


Switch pathways
Inferred: Dorso-ventral axis formation, Focal adhesion, Gap junction, GnRH signaling pathway
References

(1) Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.
Lemmon et al. J. Biol. Chem. (1994)




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