Switch #:
SWTI000369
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y220 in the SH2-binding motif of Disabled homolog 1 (DAB1) induces binding to the Adapter molecule crk (CRK) protein.

Participants:
(1) Disabled homolog 1 (DAB1)
(2) Adapter molecule crk (CRK)

Interactions
Interaction #1 DAB1 - CRK

Interfaces
(1) ELM:LIG_SH2_IB motif (211RDPETEENIYQVPTSQKKEG230) in Disabled homolog 1 (DAB1)
(2) SH2 domain (13-104) in Adapter molecule crk (CRK)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y220 on Disabled homolog 1 (DAB1)) of the Disabled homolog 1 (DAB1) LIG_SH2_IB motif - Adapter molecule crk (CRK) SH2 domain interaction

References

(1) Interaction between Dab1 and CrkII is promoted by Reelin signaling.
Chen et al. J. Cell. Sci. (2004)




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