Switch #:
SWTI000363
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y220 in the SH2-binding motif of Linker for activation of T-cells family member 1 (LAT) induces binding to the GRB2-related adaptor protein 2 (Grap2) protein.

Participants:
(1) Linker for activation of T-cells family member 1 (LAT)
(2) GRB2-related adaptor protein 2 (Grap2)

Interactions
Interaction #1 LAT - Grap2

Interfaces
(1) ELM:LIG_SH2_IC motif (218REYVNV223) in Linker for activation of T-cells family member 1 (LAT)
(2) SH2 domain (58-132) in GRB2-related adaptor protein 2 (Grap2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y220 on Linker for activation of T-cells family member 1 (LAT)) of the Linker for activation of T-cells family member 1 (LAT) LIG_SH2_IC motif - GRB2-related adaptor protein 2 (Grap2) SH2 domain interaction

Additional Information
Affinity : 45.34 µM
Structural information: 1R1P
References

(1) Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads.
Cho et al. EMBO J. (2004)




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