Switch #:
SWTI000360
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y177 in the SH2-binding motif of BCR/ABL fusion induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.

Participants:
(1) BCR/ABL fusion
(2) Growth factor receptor-bound protein 2 (GRB2)

Interactions
Interaction #1 BCR/ABL fusion - GRB2

Interfaces
(1) ELM:LIG_SH2_IC motif (174KPFYVNV180) in BCR/ABL fusion
(2) SH2 domain (60-135) in Growth factor receptor-bound protein 2 (GRB2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y177 on BCR/ABL fusion) of the BCR/ABL fusion LIG_SH2_IC motif - Growth factor receptor-bound protein 2 (GRB2) SH2 domain interaction

Additional Information
Structural information: 1TZE
References

(1) Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode.
Rahuel et al. Nat. Struct. Biol. (1996)




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