Description: Participants: Interactions  This is a sequential switch. The interactions in this switch take place in a defined order. The order is defined by numbers to the left of each interaction. More than one interaction can occur in each step, these interactions occur independently but are necessary for future step1Interaction #1 14-3-3zeta - 14-3-3zeta Interfaces (1) 14-3-3 protein in 14-3-3 protein zeta (14-3-3zeta) (2) 14-3-3 protein (6-239) in 14-3-3 protein zeta (14-3-3zeta) 2Interaction #2 Slob - Interaction #1 14-3-3zeta - 14-3-3zeta Requires Interaction #1 14-3-3zeta - 14-3-3zeta Interfaces (3) LIG_14-3-3_3 motif (51RSNSAI56) in Slowpoke-binding protein (Slob) (4) Interaction #1 14-3-3zeta - 14-3-3zeta Interaction Regulation PTM-dependent Induction (Phosphorylation of S54 on Slowpoke-binding protein (Slob)) of the Slowpoke-binding protein (Slob) LIG_14-3-3_3 motif - 14-3-3 protein interaction Regulatory Enzymes for switch Modifying enzymes for residue: S54: Calcium/calmodulin-dependent protein kinase type II alpha chain (CaMKII) 2Interaction #3 Slob - Interaction #1 14-3-3zeta - 14-3-3zeta Requires Interaction #1 14-3-3zeta - 14-3-3zeta Interfaces (5) LIG_14-3-3_3 motif (76RSASSE81) in Slowpoke-binding protein (Slob) (6) Interaction #1 14-3-3zeta - 14-3-3zeta Interaction Regulation PTM-dependent Induction (Phosphorylation of S79 on Slowpoke-binding protein (Slob)) of the Slowpoke-binding protein (Slob) LIG_14-3-3_3 motif - 14-3-3 protein interaction Regulatory Enzymes for switch Modifying enzymes for residue: S79: Calcium/calmodulin-dependent protein kinase type II alpha chain (CaMKII) Context Switch localisation Curated: cytoplasmic side of plasma membrane ELM curated: nucleus, cytosol, internal side of plasma membrane References (1) A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channel complex in Drosophila presynaptic nerve terminals. |
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