Switch #:
SWTI000348
Switch type:
Avidity-sensing

Description:
Phosphorylation of Y142 and Y153 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).

Participants:
(1) T-cell surface glycoprotein CD3 zeta chain (CD247)
(2) Tyrosine-protein kinase ZAP-70 (ZAP70)

Interactions
Interaction #1 CD247 - ZAP70

Interfaces
(1) LIG_TYR_ITAM motif (139DGLYQGLSTATKDTYDAL156) in T-cell surface glycoprotein CD3 zeta chain (CD247)
(2) SH2 domain (10-87) in Tyrosine-protein kinase ZAP-70 (ZAP70)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y142 and Y153 on T-cell surface glycoprotein CD3 zeta chain (CD247)) of the T-cell surface glycoprotein CD3 zeta chain (CD247) LIG_TYR_ITAM motif - Tyrosine-protein kinase ZAP-70 (ZAP70) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y142 : Tyrosine-protein kinase Lck (LCK).

Interaction #2 CD247 - ZAP70

Interfaces
(3) LIG_TYR_ITAM motif (139DGLYQGLSTATKDTYDAL156) in T-cell surface glycoprotein CD3 zeta chain (CD247)
(4) SH2 domain (163-239) in Tyrosine-protein kinase ZAP-70 (ZAP70)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y142 and Y153 on T-cell surface glycoprotein CD3 zeta chain (CD247)) of the T-cell surface glycoprotein CD3 zeta chain (CD247) LIG_TYR_ITAM motif - Tyrosine-protein kinase ZAP-70 (ZAP70) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y142 : Tyrosine-protein kinase Lck (LCK).

Context
References

(1) Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance.
Bu et al. Proc. Natl. Acad. Sci. U.S.A. (1995)




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