Description: Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
Participants: (1) T-cell surface glycoprotein CD3 zeta chain (CD247) (2) Tyrosine-protein kinase ZAP-70 (ZAP70)
(1) The role of tyrosine phosphorylation in the interaction of cellular tyrosine kinases with the T cell receptor zeta chain tyrosine-based activation motif.Osman et al. Eur. J. Immunol. (1995) (2) Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance.Bu et al. Proc. Natl. Acad. Sci. U.S.A. (1995)
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