Description: Phosphorylation of Y72 and Y83 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).
Participants: (1) T-cell surface glycoprotein CD3 zeta chain (CD247) (2) Tyrosine-protein kinase ZAP-70 (ZAP70)
(1) Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance.Bu et al. Proc. Natl. Acad. Sci. U.S.A. (1995) (2) Functional analysis of immunoreceptor tyrosine-based activation motif (ITAM)-mediated signal transduction: the two YxxL segments within a single CD3zeta-ITAM are functionally distinct.Sunder-Plassmann et al. Eur. J. Immunol. (1997)
