Description: The PDZ domains of Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) and SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) compete for the PDZ-binding motif of Cystic fibrosis transmembrane conductance regulator (CFTR). SLC9A3R1 positively regulates CFTR activity by recruiting a PKA-containing complex, while SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) negatively affects CFTR activity by recruiting PDE4D.
Participants: (1) Cystic fibrosis transmembrane conductance regulator (CFTR) (2) Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) (3) SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
(1) Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors.Lee et al. J. Biol. Chem. (2007)
