Switch #:
SWTI000333
Switch type:
Specificity
Switch subtype:
Domain hiding

Description:
Binding of Ezrin via its FERM domain to the EB domain of Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) results in allosteric coupling to the second PDZ domain of SLC9A3R1. This relieves the intramolecular interaction with the SLC9A3R1 PDZ-binding ligand and increases the affinity of the PDZ domain for other ligands including Catenin beta-1 (CTNNB1).

Participants:
(1) Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)
(2) Catenin beta-1 (CTNNB1)

Interactions
Interaction #1 SLC9A3R1 - SLC9A3R1(intramolecular)
intramolecular
Is mutually exclusive with Interaction #2 CTNNB1 - SLC9A3R1

Interfaces
(1) LIG_PDZ_Class_1 motif (353ELFSNL358) in Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)
(2) PDZ domain (Also known as DHR or GLGF) (154-231) in Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)
Additional Information
Structural information: 2KRG
Context
References

(1) A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation.
Bhattacharya et al. J. Biol. Chem. (2010)




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